CD11b Antibody [3A33] (PE-Cy5) | 98-637

CD11b Antibody [3A33] (PE-Cy5) | 98-637 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: Peritoneal macrophages from B6D2 hybrid mice

Research Area: Immunology, Neuroscience, Signal Transduction

Tested Application: E

Application: CD11b Antibody [3A33] for use in flow cytometry assays.

Specificiy: CD11b

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [3A33]

Isotype: IgG2a

Conjugate: PE-Cy5

Physical State: Liquid

Buffer: Supplied in PBS/NaN3 and a stabilizing agent

Concentration: 0.1 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD11b (integrin alphaM subunit) combines with CD18 (integrin beta2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3) , which mediates adhesion to C3bi and ICAM-1 (CD54) . Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.