CD11b Antibody [M1/70] (PE-Cy7) | 76-132

CD11b Antibody [M1/70] (PE-Cy7) | 76-132 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Human, Mouse

Homology: N/A

Immunogen: N/A

Research Area: Innate Immunity

Tested Application: Flow

Application: N/A

Specificiy: The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) .

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clonality: Monoclonal

Clone: M1/70

Isotype: Rat IgG2b, kappa

Conjugate: PE-Cy7

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

Alternate Name: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) . Mac-1 binds to C3bi, CD54 (ICAM-1) , and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.