CD11c polyclonal Antibody | BS90211

CD11c polyclonal Antibody | BS90211 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC IP

Application Range: WB:1:1,000-1:2,000 IHC:1:50-1:200

Background: Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4) . Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD11c polyclonal Antibody detects endogenous levels of CD11c protein.

Molecular Weight: 128 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ITGAX, 95 alpha chain, 95, CD 11c, CD11 antigen-like family member C, CD11c, CD11c antigen, Complement component 3 receptor 4 subunit, CR4, Integrin alpha X, Integrin alpha X chain, Integrin alpha-X, Integrin aX, Integrin subunit alpha X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), integrin, alpha X (complement component 3 receptor 4 subunit, ITAX, ITGAX, LEU M5 alpha subunit, Leu M5, Leukocyte adhesion glycoprotein p150 95 alpha chain, Leukocyte adhesion glycoprotein p150, Leukocyte adhesion receptor p150 95, Leukocyte adhesion receptor p150, Leukocyte surface antigen p150 95 alpha subunit, Leukocyte surface antigen p150 alpha subunit, Myeloid membrane antigen alpha subunit, p150 95 integrin alpha chain, p150, p150/95, SLEB6,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: