CD152 Antibody [UC10-4F10-11] | 76-850

CD152 Antibody [UC10-4F10-11] | 76-850 | Gentaur UK, US & Europe Distribution

Host: Hamster

Reactivity: Mouse

Homology: N/A

Immunogen: N/A

Research Area: Immunology

Tested Application: Flow

Application: N/A

Specificiy: The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) , also known as CD152.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Clonality: Monoclonal

Clone: UC10-4F10-11

Isotype: Armenian Hamster IgG1, kappa

Conjugate: Unconjugated

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.

Alternate Name: Cd152, Ly-56, Ctla-4, Ctla4

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) , also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86) , with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.