CD163 Rabbit Polyclonal Antibody, for Western | A2301

CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that is exclusively expressed in monocytes and macrophages. It mediates the clearance of hemoglobin/haptoglobin complexes by macrophages, which may protect tissues from free hemoglobin-mediated oxidative damage. CD163 may also mediate innate immunity against bacteria, and plays a role in inflammatory responses. CD163 is upregulated in many inflammatory diseases including liver cirrhosis and rheumatoid arthritis. CD163 expression is associated with Hodgkin lymphoma, and correlates with poor survival outcomes in glioma cases. Recent studies have shown that the depletion of macrophages expressing CD163 can result in a massive recruitment of activated T cells into tumor microenvironments, suggesting a role for CD163 in tumor progression.

A2301 | CD163 Rabbit Polyclonal Antibody, for Western DataSheet

Antibody Target: Human CD163

Target Alternative Name: M130; MM130; SCARI1

Tag Line: Plays a role in inflammatory responses

Category: GM-CSF

Host: Rabbit

Isotype: IgG

Species Reactivities: Human Mouse Rat

Immunogen Sequence: Recombinant full length protein of human CD163

Accession #: Q86VB7

Gene ID: 9332

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: In 0.42% potassium phosphate, 0.87% sodium chloride, 30% glycerol; 0.01% sodium azide, pH 7.3

Purification: Affinity purification

Application: Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified:

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified:

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE