CD19 Mouse monoclonal Antibody | MB9024

CD19 Mouse monoclonal Antibody | MB9024 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, mouse

Application: WB IHC FC

Application Range: WB: 1:500 IHC: 1:100-1:200 FC: 1:100-1:200

Background: CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is selectively expressed on the cell surface of B-lymphocytes, where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways. Activation of CD19 results in cross-linking of the membrane protein immunoglobulin chains and the subsequent association with Src family protein tyrosine kinases (PTK) . Expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. CD19 forms functional complexes with B-lymphocyte surface proteins, including integrin β1, CD21 and CD81, which are involved in regulating B-cell development.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of CD19 and does not cross-react with related proteins.

Molecular Weight: ~ 61, 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12;

Immunogen: This Antibody is produced by immunizing mice with a recombinant protein corresponding to a region of CD19.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified

Pathway: PI3K AKT signaling,T cell receptor signaling,Adherens Junction signaling,MTOR signaling,