Description
CD22 Antibody [2D6] (APC) | 98-680 | Gentaur UK, US & Europe Distribution
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
Research Area: Cancer, Stem Cell, Immunology
Tested Application: E, WB, IHC-P, ICC, Flow, IP
Application: CD22 Antibody [2D6] for use in flow cytometry assays.
Specificiy: CD22
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [2D6]
Isotype: IgG1
Conjugate: APC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Lyb-8, Leu-14, BL-CAM
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage) , appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.