CD272 (W153) polyclonal Antibody | BS9212

CD272 (W153) polyclonal Antibody | BS9212 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: B and T lymphocyte attenuator (BTLA,CD272) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are co-inhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T cell activation by propagating inhibitory signals through BTLA. The BTLA-HVEM interaction is conserved between mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD272 (W153) polyclonal Antibody detects endogenous levels of CD272 protein.

Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA

Immunogen: Synthetic peptide, corresponding to amino acids 120-176 of Human CD272.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: