Description
CD2AP Polyclonal Antibody | E-AB-16309 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: Adapter protein CMS, AL024079, C78928, Cas ligand with multiple SH3 domains, CD2 associated protein, CD2-associated protein, CD2AP, CD2AP, CMS, Mesenchyme to epithelium transition protein with SH3 domains 1, METS 1, Mets1
Application: WB, IHC, ELISA
Reactivity: Human
Host: Rabbit
Isotype: IgG
Reserch Areas: Signal transduction
Background: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Concentration: 0.2 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human CD2AP
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:1000-1:5000, IHC 1:100-1:300
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 71 kDa
Molecular Weight(Observed): N/A