Description
CD30 Antibody [mCD30.1] | 98-731 | Gentaur UK, US & Europe Distribution
Host: Hamster
Reactivity: Mouse
Homology: N/A
Immunogen: Mouse CD30-mouse IgG1 fusion protein
Research Area: Apoptosis
Tested Application: ICC, Flow
Application: CD30 Antibody [mCD30.1] for use in flow cytometry, costimulation, stimulation, and blocking assays.
Specificiy: CD30
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [mCD30.1]
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in PBS
Concentration: 0.5 mg/mL
Storage Condition: Store vial at -20˚C
Alternate Name: Ki-1, Ber-H2
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3epsilon-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-gamma production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.