CD4 polyclonal Antibody | BS90243

CD4 polyclonal Antibody | BS90243 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC

Application Range: WB:1:500 FC:1:50-1:100

Background: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Specificity: CD4 polyclonal Antibody detects endogenous levels of CD4 protein.

Molecular Weight: 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD4, CD 4, CD4 (L3T4), CD4, CD4 antigen (p55), CD4 antigen, CD4 molecule, CD4 receptor, CD4+ Lymphocyte deficiency, included, CD4, CD4mut, L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, MGC165891, OTTHUMP00000238897, p55, T cell antigen T4, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T cell OKT4 deficiency, included, T cell surface antigen T4/Leu 3, T cell surface antigen T4/Leu3, T cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, W3/25, W3/25 antigen Antibody

Immunogen: Recombinant protein with Human CD4 1-300 aa.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,