CD40 Antibody| F45979-0.08ML/F45979-0.4ML/F53687-0.1ML/R30192/V3694-20UG/V3694IHC-7ML

CD40 Antibody| F45979-0.08ML/F45979-0.4ML/F53687-0.1ML/R30192/V3694-20UG/V3694IHC-7ML | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Pig

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the CD40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CD40 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 247-276 from the human protein was used as the immunogen for this CD40 antibody.

Storage: Aliquot the CD40 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A