CD51 Antibody [13C2] | 99-550

CD51 Antibody [13C2] | 99-550 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, African Green Monkey, Rabbit, Bovine

Homology: N/A

Immunogen: Cell suspension containing osteoclasts from osteoclastomas

Research Area: Other

Tested Application: Flow

Application: CD51 Antibody [13C2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, purification, depletion, adhesion, and blocking assays.

Specificiy: CD51

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [13C2]

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

Concentration: 0.1 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Integrin alphaV, vitronectin receptor, VNR-alpha chain

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD51 represents the integrin alphaV chain that associates with integrin beta3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin alpha subunit as it can form heterodimers with the beta1 (CD29) , beta3 (CD61) , beta5, beta6 and beta8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.