CD95 Antibody [DX2] | 99-581

CD95 Antibody [DX2] | 99-581 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rhesus, African Green Monkey, Sooty Mangabey

Homology: N/A

Immunogen: Human CD95 transfected L cells

Research Area: Cancer, Cell Cycle, Immunology, Signal Transduction

Tested Application: Flow, IP

Application: CD95 Antibody [DX2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, and apoptosis assays.

Specificiy: CD95

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [DX2]

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in PBS

Concentration: 0.5 mg/mL

Storage Condition: Store vial at -20˚C

Alternate Name: APO-1, Fas, TNFRSF6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.