CD95 Antibody [DX2] (PE) | 99-579

CD95 Antibody [DX2] (PE) | 99-579 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rhesus, African Green Monkey, Sooty Mangabey

Homology: N/A

Immunogen: Human CD95 transfected L cells

Research Area: Cancer, Cell Cycle, Immunology, Signal Transduction

Tested Application: Flow

Application: CD95 Antibody [DX2] for use in flow cytometry assays.

Specificiy: CD95

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [DX2]

Isotype: IgG1

Conjugate: PE

Physical State: Liquid

Buffer: Supplied in PBS/NaN3 and a stabilizing agent

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: APO-1, Fas, TNFRSF6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.