CDK4 Antibody [3F6A4] | 13-006

CDK4 Antibody [3F6A4] | 13-006 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant protein of human CDK4

Research Area: Cancer, Cell Cycle, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:1000
IHC: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: A-431

Positive Control 2: HeLa

Positive Control 3: NIH/3T3

Positive Control 4: Mouse thymus

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 34kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Monoclonal

Clone: [3F6A4]

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, pH7.3.

Concentration: N/A

Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.

Alternate Name: CDK4, CMM3, PSK-J3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.