749
Cdk6 Polyclonal Antibody | ABP58091
- SKU:
- 749-ABP58091
- Availability:
- Usually ships in 5 working days
Description
Cdk6 Polyclonal Antibody | ABP58091 | Gentaur UK, US & Europe Distribution
Immunogen: Synthesized peptide derived from part region of human Cdk6 protein at amino acid sequence of 280-325
Product Category: Protein
Application: Protein General Reagents
Product Type: Primary Antibody
Host: Rabbit
Reactivity: Human
Application: WB, IHC-P, ELISA
Application Note: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:500-1:200), ELISA (1:10000-1:20000) .
Clonality: Polyclonal
Isotype: Rabbit IgG
Formulation: Liquid solution
Kit Component: N/A
Concentration: 1 mg/ml
Storage Buffer: PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol as stabilizer.
Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Condition: Gel pack with blue ice.
Background: Cdk6 protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of Cdk6 protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.
Alternative Names: Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE
Precaution: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.