Cdk9 Inhibitor II | B2903

Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM and 20 µM respectively. It reduces the frequency of S-phase cells in the cancer cell line HT-29 and decreases the phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II. It inhibits mRNA synthesis and induces the tumor suppressor protein p53. It inhibits cell proliferation of cancer cell lines such as MCF-7, HOS, G361, and K562 cells with IC₅₀ values of 33 µM, 49 µM, 64 µM, and 62 µM respectively.

Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM and 20 µM respectively. It reduces the frequency of S-phase cells in the cancer cell line HT-29 and decreases the phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II. It inhibits mRNA synthesis and induces the tumor suppressor protein p53. It inhibits cell proliferation of cancer cell lines such as MCF-7, HOS, G361, and K562 cells with IC₅₀ values of 33 µM, 49 µM, 64 µM, and 62 µM respectively.

B2903 | Cdk9 Inhibitor II DataSheet

Alternate Name/Synonyms: CAY10574; UNII-ZG0O47K626; ZG0O47K626; CAN508; 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol; 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol; 3,5-diamino-4-(4-hydroxyphenyl)azopyrazole; 4-Arylazo-3,5-diamino-1H-pyrazole 31b

Appearance: A crystalline solid

Formulation:

CAS Number: 140651-18-9

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₉H₁₀N₆O

Molecular Weight: 218.22

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~0.5 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective inhibitor of Cdk9

MDL Number: MFCD09262258

PubChem CID: 135398514

SMILES: C1=CC(=CC=C1N=NC2=C(NN=C2N)N)O

InChi: InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)

InChi Key: