AKR1C3 Inhibitor II | 2404

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.

AKR1C3 inhibitor II is a highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM).

2404 | AKR1C3 Inhibitor II DataSheet

Alternate Name/Synonyms: 1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₆H₂₂N₂O₃S

Molecular Weight: 322.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent and selective AKR1C3 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C1N(C2=CC=C(S(=O)(N3C(C)CCCC3)=O)C=C2)CCC1

InChi: InChI=1S/C16H22N2O3S/c1-13-5-2-3-12-18(13)22(20,21)15-9-7-14(8-10-15)17-11-4-6-16(17)19/h7-10,13H,2-6,11-12H2,1H3

InChi Key: KCSTYGPHSVKBQP-UHFFFAOYSA-N