AKR1C3 Inhibitor III | 2424

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 88 nM). Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.

AKR1C3 inhibitor III is a highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 88 nM). Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4.

2424 | AKR1C3 Inhibitor III DataSheet

Alternate Name/Synonyms: 4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₅H₂₀ClN₃O₂

Molecular Weight: 309.79

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective AKR1C3 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(N1CCN(C2=CC=C(Cl)C=C2)CC1)N3CCOCC3

InChi: InChI=1S/C15H20ClN3O2/c16-13-1-3-14(4-2-13)17-5-7-18(8-6-17)15(20)19-9-11-21-12-10-19/h1-4H,5-12H2

InChi Key: KDSIRFZJOTZBPT-UHFFFAOYSA-N