CDKN1C Antibody | 7015

CDKN1C Antibody | 7015 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (88%)

Immunogen: CDKN1C antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CDKN1C.
The immunogen is located within amino acids 40 - 90 of CDKN1C.

Research Area: Cancer, Cell Cycle

Tested Application: E, WB, IF

Application: CDKN1C antibody can be used for detection of CDKN1C by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kDa in SDS-PAGE. CDKN1C antibody is predicted to not cross react with other CIP/KIP proteins.

Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate

Positive Control 2: Cat. No. 17-010 - HEK293 Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 35 kDa

Validation: N/A

Isoform: N/A

Purification: CDKN1C Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CDKN1C antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: CDKN1C Antibody: BWS, WBS, p57, BWCR, KIP2, p57Kip2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C) , also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.