CDO1 Antibody | 8137

CDO1 Antibody | 8137 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Bovine: (84%)

Immunogen: CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1.
The immunogen is located within amino acids 30 - 80 of CDO1.

Research Area: Homeostasis

Tested Application: E, WB

Application: CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Specificiy: CDO1 antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1464 - Rat Liver Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 22 kDa
Observed: 24 kDa

Validation: N/A

Isoform: N/A

Purification: CDO1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CDO1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CDO1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1) . CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1, 2) . CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1) . CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3, 4) .