Description
CDO1 Antibody | 8137 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (84%)
Immunogen: CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1.
The immunogen is located within amino acids 30 - 80 of CDO1.
Research Area: Homeostasis
Tested Application: E, WB
Application: CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Specificiy: CDO1 antibody is human, mouse and rat reactive.
Positive Control 1: Cat. No. 1464 - Rat Liver Tissue Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 22 kDa
Observed: 24 kDa
Validation: N/A
Isoform: N/A
Purification: CDO1 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: CDO1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: CDO1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1) . CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1, 2) . CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1) . CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3, 4) .