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CELF1 monoclonal Antibody | MB9151

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BW-MB9151
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Description

CELF1 monoclonal Antibody | MB9151 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: IHC WB

Application Range: IHC:1:50-1:200 WB:1:2,000-1:5,000

Background: Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG) n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK) . CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG) 8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: CELF1 monoclonal Antibody detects endogenous levels of CELF1 protein.

Molecular Weight: 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CELF-1, CUG-BP1, EDEN-BP homolog, CELF1, BRUNOL2, CUGBP, CUGBP1, NAB50, 50 kDa Nuclear polyadenylated RNA binding protein, 50 kDa nuclear polyadenylated RNA-binding protein, Bruno like 2, bruno like protein 2, Bruno-like protein 2, BRUNOL 2, BRUNOL2, CELF 1, CELF-1, celf1, CELF1 CUGBP, Elav like family member 1, CELF1, CUG BP and ETR 3 like factor 1, CUG BP, CUG BP1, CUG RNA binding protein, CUG triplet repeat RNA binding protein 1, CUG triplet repeat RNA-binding protein 1, CUG-BP, CUG-BP- and ETR-3-like factor 1, CUG-BP1, CUGBP 1, CUGBP and ETR3 like factor 1, CUGBP, CUGBP Elav like family member 1, CUGBP Elav-like family member 1, CUGBP1, Cytidine uridine guanosine binding protein 1, Deadenylation factor CUG BP, Deadenylation factor CUG-BP, Deadenylation factor CUGBP, EDEN BP, EDEN BP homolog, EDEN-BP, EDEN-BP homolog, embryo deadenylation element binding protein, embryo deadenylation element binding protein homolog, Embryo deadenylation element-binding protein homolog, hNab 50, hNab50, NAB 50, NAB50, NAPOR, Nuclear polyadenylated RNA binding protein 50 kD, Nuclear polyadenylated RNA binding protein, RNA binding protein BRUNOL 2, RNA binding protein BRUNOL2, RNA-binding protein BRUNOL-2,

Immunogen: Recombinant protein within human CELF1 aa 1-180.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway:

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