Chenodeoxycholic acid | 2831

Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. EC50 concentrations for activation of FXR (farnesoid X receptor) range from 13-34 μM. In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometery of 1:2.

Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. EC50 concentrations for activation of FXR (farnesoid X receptor) range from 13-34 μM. In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometery of 1:2.

2831 | Chenodeoxycholic acid DataSheet

Alternate Name/Synonyms: CDCA; Fluibil; Hekbilin; Anthropodeoxycholic Acid; Kebilis; Ulmenide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 474-25-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₄₀O₄

Molecular Weight: 392.57

Cell-Permeable?: No

Purity: ≥95%

Solubilities: EtOH (50 mg/ml)

Handling: Hygroscopic

Country of Origin: USA

Tag Line: A bile acid and FXR ligand

MDL Number: MFCD00064142

PubChem CID: 10133

SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

InChi: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

InChi Key: RUDATBOHQWOJDD-BSWAIDMHSA-N