Chetomin | 2180

A natural metabolite produced by genus Chaetomium. Acts as an inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Histone H3K9 methyltransferases G9a and Suv39h inhibitor. Also acts as an immunosuppressant.

Chetomin is a natural metabolite produced by genus Chaetomium. Acts as an inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Histone H3K9 methyltransferases G9a and Suv39h inhibitor.

2180 | Chetomin DataSheet

Alternate Name/Synonyms:

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1403-36-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₀N₆O₆S₄

Molecular Weight: 710.87

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A HIF-1 inhibitor

MDL Number: MFCD01745887

PubChem CID: 73583

SMILES: CN1C(=O)C2(N(C(=O)C1(SS2)CC3=CN(C4=CC=CC=C43)C56CC78C(=O)N(C(C(=O)N7C5NC9=CC=CC=C69)(SS8)CO)C)C)CO

InChi: InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32, 38-39H,12,14-16H2,1-3H3/t22-,27+,28-,29+,30+,31+/m1/s1

InChi Key: ZRZWBWPDBOVIGQ-OKMJTBRXSA-N