A natural metabolite produced by genus Chaetomium. Acts as an inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Histone H3K9 methyltransferases G9a and Suv39h...
BC-1618 is a potent Fbxo48 inhibitory compound that stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). Fbxo48 and was much more potent than...