Chidamide | 2261

Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.

Chidamide is a new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM.

2261 | Chidamide DataSheet

Alternate Name/Synonyms: N-​(2-​amino-​5-​fluorophenyl)-​4-​[[[1-​oxo-​3-​(3-​pyridinyl)-​2-​propen-​1-​yl]amino]methyl]-​benzamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 743420-02-2

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₂H₁₉FN₄O₂

Molecular Weight: 390.41

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A potent histone deacetylase inhibitor

MDL Number: N/A

PubChem CID: 53394037

SMILES: C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=CC(=C3)F)N

InChi: InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)

InChi Key: WXHHICFWKXDFOW-UHFFFAOYSA-N