Description
Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.
Chidamide is a new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM.
Alternate Name/Synonyms: N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 743420-02-2
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₂₂H₁₉FN₄O₂
Molecular Weight: 390.41
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO
Handling: Protect from light and mositure
Country of Origin: USA
Tag Line: A potent histone deacetylase inhibitor
MDL Number: N/A
PubChem CID: 53394037
SMILES: C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=CC(=C3)F)N
InChi: InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)
InChi Key: WXHHICFWKXDFOW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |