CHIT1 Antibody | 18-448

CHIT1 Antibody | 18-448 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1) .

Research Area: Immunology, Innate Immunity

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: U-251MG

Positive Control 2: 293T

Positive Control 3: Mouse spleen

Positive Control 4: Mouse skeletal muscle

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 52kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CHIT1, plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase, OTTHUMP00000217085, OTTHUMP00000217084, OTTHUMP00000217083, MGC125322, FLJ00314, chitotriosidase-1, chitinase-1, chitinase 1 (chitotriosidase) , CHIT, CHI3, CHITD

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.