Description
Cell-permeable. CID-2011756 is an ATP-competitive protein kinase D (PKD) inhibitor with IC₅₀ values of 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively. Inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells.
CID-2011756 is an ATP-competitive protein kinase D (PKD) inhibitor with IC₅₀ values of 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively. Inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells.
Alternate Name/Synonyms: 5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 638156-11-3
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₁ClN₂O₃
Molecular Weight: 396.87
Cell-Permeable?: Yes
Purity: >98% by HPLC
Solubilities: DMSO (~ 18 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A protein kinase D (PKD) inhibitor
MDL Number: MFCD04094273
PubChem CID: 2011756
SMILES: C1COCCN1CC2=CC=C(C=C2)NC(=O)C3=CC=C(O3)C4=CC(=CC=C4)Cl
InChi: nChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26)
InChi Key: XQJWTJLJEYIUDZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |