26
Cinacalcet hydrochloride | B3297
- SKU:
- 26-B3297-GEN
- Availability:
- Usually shipped in 5 working days
Description
Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels.
Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels.
B3297 | Cinacalcet hydrochloride DataSheet
Alternate Name/Synonyms: Mimpara AMG 073 αR-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride KRN1493
Appearance: White solid
Formulation:
CAS Number: 364782-34-3
Structure Available?: Yes
Peptide sequence:
Salt Form:
Molecular Formula: C₂₂H₂₂F₃N.HCl
Molecular Weight: 393.87
Cell-Permeable?: False
Purity: ≥98% by HPLC
Solubilities: >35 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An allosteric agonist of the calcium-sensing receptor
MDL Number:
PubChem CID: 156418
SMILES: CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
InChi: InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
InChi Key: QANQWUQOEJZMLL-PKLMIRHRSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |