CIR Antibody (N-term) [APR31210G]

CIR Antibody (N-term) [APR31210G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from the N-terminal region of human CIR.

Cellular Localisation: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome

Molecular Weight: 52313

Clone: Polyclonal

Gene Name: CIR1

Gene ID: 9541

Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity) . Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) . Required for RBPJ-mediated repression of transcription.

Summary: Tissue Location: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR