Citrullinated Histone H1.4 (R53) Antibody | A2317

Histone H1.4 is a nuclear protein that binds to linker DNA between nucleosomes to form chromatin fibers. Histone H1.4 is expressed in most somatic cell types, and is necessary for the ordering of nucleosomes into higher-order structures and the compaction of chromatin into its condensed form. The arginine at position 53 can be citrullinated by protein-arginine deiminase 4 (PAD4), which releases Histone H1.4 from the histone complex, leading to chromatin decondensation. Aberrations in Histone H1.4 has been linked to intellectual disability disorders such as Rahman Syndrome.

A2317 | Citrullinated Histone H1.4 (R53) Antibody DataSheet

Antibody Target: Human Histone H1.4 citrullinated at R53

Target Alternative Name: H1.4 Linker Histone, Cluster Member; Histone Cluster 1 H1 Family Member E; H1 Histone Family, Member 4; Histone Cluster 1, H1e; Histone 1, H1e; Histone H1s-4; Histone H1.4; Histone H1b; HIST1H1E; H1s-4; H1.4; H1F4; DJ221C16.5; RMNS; H1-4; H1E; H1e

Tag Line: A critical mediator of higher-order chromatin structure

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human

Immunogen Sequence: Synthetic peptide of human histone H1.4 citrullinated at R53

Accession #: P10412

Gene ID: 3008

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide

Purification: Peptide affinity purification

Application: Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE