Histone H3 (Citrullinated R2, R8, R17) Antibody | A2318

Histone H3 is a nuclear protein that is a component of the histone complex that is essential for the organization of genetic material in eukaryotes. Histone H3 can be citrullinated by protein argine deiminase 4 (PAD4) at positions 2, 8, and 17, which blocks methylation and induces transcriptional repression at target genes. The citrullinated histone H3 is found in neutrophil extracellular traps (NETs), which act to induce production of autoantibodies associated with various diseases such as multiple sclerosis and rheumatoid arthritis.

A2318 | Histone H3 (Citrullinated R2, R8, R17) Antibody DataSheet

Antibody Target: Citrullinated Human Histone H3

Target Alternative Name: Histone H3; H3 Clustered Histone 1; H3/A; Histone H3.1; Histone H3/A

Tag Line: A potential autoimmune disease biomarker

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human

Immunogen Sequence: Histone H3 peptide citrullinated at R2, R8, and R17

Accession #: P64831

Gene ID: 8350

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide

Purification: Peptide affinity purification

Application: ELISA Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE