26
Histone H3 (Citrullinated R2, R8, R17) Antibody | A2318
- SKU:
- 26-A2318-GEN
- Availability:
- Usually shipped in 5 working days
Description
Histone H3 is a nuclear protein that is a component of the histone complex that is essential for the organization of genetic material in eukaryotes. Histone H3 can be citrullinated by protein argine deiminase 4 (PAD4) at positions 2, 8, and 17, which blocks methylation and induces transcriptional repression at target genes. The citrullinated histone H3 is found in neutrophil extracellular traps (NETs), which act to induce production of autoantibodies associated with various diseases such as multiple sclerosis and rheumatoid arthritis.
A2318 | Histone H3 (Citrullinated R2, R8, R17) Antibody DataSheet
Antibody Target: Citrullinated Human Histone H3
Target Alternative Name: Histone H3; H3 Clustered Histone 1; H3/A; Histone H3.1; Histone H3/A
Tag Line: A potential autoimmune disease biomarker
Category: GM-CSF
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: Histone H3 peptide citrullinated at R2, R8, and R17
Accession #: P64831
Gene ID: 8350
Appearance: Liquid
Form: Rabbit polyclonal
Concentration:
Formulation: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide
Purification: Peptide affinity purification
Application: ELISA Western Blotting
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: TRUE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |