CL-387785 | 2826

CL-387785 is an irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated growth.

CL-387785 is an irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated growth.

2826 | CL-387785 DataSheet

Alternate Name/Synonyms: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; EKI-785

Appearance: Off-white solid

Formulation: N/A

CAS Number: 194423-06-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃BrN₄O

Molecular Weight: 381.23

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An irreversible EGFR kinase inhibitor

MDL Number: N/A

PubChem CID: 2776

SMILES: CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br

InChi: InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)

InChi Key: BTYYWOYVBXILOJ-UHFFFAOYSA-N