Description
CL-387785 is an irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated growth.
CL-387785 is an irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated growth.
Alternate Name/Synonyms: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; EKI-785
Appearance: Off-white solid
Formulation: N/A
CAS Number: 194423-06-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₃BrN₄O
Molecular Weight: 381.23
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>100 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An irreversible EGFR kinase inhibitor
MDL Number: N/A
PubChem CID: 2776
SMILES: CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
InChi: InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)
InChi Key: BTYYWOYVBXILOJ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |