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Cl-Amidine (hydrochloride) | B2802
- SKU:
- 26-B2802-GEN
- Availability:
- Usually shipped in 5 working days
Description
Cl-Amidine (hydrochloride) is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor. It catalyzes the post-translational modification of arginine residues on histones to form citrulline. The in vitro IC₅₀ values are 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It causes apoptosis in multiple cancer cell lines such as HL60, HT29, TK6, and U2-OS cells. It improves disease phenotypes in animal models of inflammatory arthritis and inflammatory bowel disease. It reduces the development of IgG autoantibodies in a collagen-induced mouse model of inflammatory arthritis.
Cl-Amidine (hydrochloride) is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor. It catalyzes the post-translational modification of arginine residues on histones to form citrulline. The in vitro IC₅₀ values are 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It causes apoptosis in multiple cancer cell lines such as HL60, HT29, TK6, and U2-OS cells. It improves disease phenotypes in animal models of inflammatory arthritis and inflammatory bowel disease. It reduces the development of IgG autoantibodies in a collagen-induced mouse model of inflammatory arthritis.
B2802 | Cl-Amidine (hydrochloride) DataSheet
Alternate Name/Synonyms: Cl-amidine (hydrochloride), N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride, (2S)-5-(2-chloroethanimidamido)-2-(phenylformamido)pentanamide hydrochloride, (S)-N-(1-amino-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)benzamide hydrochloride, N-(1S)-1-(Aminocarbonyl)-4-(2-chloro-1-iminoethyl)aminobutyl-benzamide hydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: 1373232-26-8
Structure Available?: True
Peptide sequence:
Salt Form: True
Molecular Formula: C₁₄H₂₀Cl₂N₄O₂
Molecular Weight: 347.24
Cell-Permeable?: True
Purity: ≥95%
Solubilities: 50 mg/ml in in DMSO, 14 mg/ml in DMF in 0, ~20 mg/ml in in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An irreversible pan-peptidylarginine deiminase (PAD) inhibitor.
MDL Number:
PubChem CID: 74889978
SMILES: C1=CC=C(C=C1)C(=O)NC(CCCN=C(CCl)N)C(=O)N.Cl
InChi: InChI=1S/C14H19ClN4O2.ClH/c15-9-12(16)18-8-4-7-11(13(17)20)19-14(21)10-5-2-1-3-6-10;/h1-3,5-6,11H,4,7-9H2,(H2,16,18)(H2,17,20)(H,19,21);1H/t11-;/m0./s1
InChi Key: OPFMEGSAOZAJIV-MERQFXBCSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36months |