CLC4 Antibody (C-term) [APR10865G]

CLC4 Antibody (C-term) [APR10865G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.

Cellular Localisation: Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3

Molecular Weight: 84917

Clone: Polyclonal

Gene Name: CLCN4

Gene ID: 1183

Function: Strongly outwardly rectifying, electrogenic H (+) /Cl (-) exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:28972156, PubMed:23647072, PubMed:27550844, PubMed:25644381) . The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874) . The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874) .

Summary: Tissue Location: Abundant in skeletal muscle and also detectable in brain and heart

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IF, IHC-P-Leica

Dilution: WB--1:1000 IF--1:10~50 IHC-P-Leica--1:100~500

Synonyms: H (+) /Cl (-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4