CLDN18 Antibody (C-term) [APR15477G]

CLDN18 Antibody (C-term) [APR15477G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CLDN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids of human CLDN18.

Cellular Localisation: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells {ECO:0000250|UniProtKB:P56857}

Molecular Weight: 27856

Clone: Polyclonal

Gene Name: CLDN18

Gene ID: 51208

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Summary: Tissue Location: Isoform A1: Expression is restricted to the lung (PubMed:19047087) . Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:2000

Synonyms: Claudin-18, CLDN18