Cleaved-PARP1 (D214) Polyclonal Antibody | E-AB-30080

Cleaved-PARP1 (D214) Polyclonal Antibody | E-AB-30080 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT 1, ADPRT, ADPRT1, APOPAIN, ARTD1, NAD(+) ADP-ribosyltransferase 1, PARP, PARP-1, PARP1, PARP1, Poly [ADP-ribose] polymerase 1, Poly ADP ribose polymerase 1, Poly[ADP-ribose] synthase 1, PPOL, SCA1

Application: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from the Internal region of human PARP-1

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-2000, IHC 1:50-300, IF 1:50-300

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 113 kDa

Molecular Weight(Observed): 24 kDa