LBD
CLEC16A Antibody (C-term) [APR33094G]
- SKU:
- LBD-APR33094G
- Availability:
- Usually ships in 5 working days
Description
CLEC16A Antibody (C-term) [APR33094G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This CLEC16A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 773-805 amino acids from the C-terminal region of human CLEC16A.
Cellular Localisation: Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30}
Molecular Weight: 117715
Clone: Polyclonal
Gene Name: CLEC16A (HGNC:29013)
Gene ID: 23274
Function: Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Summary: Tissue Location: Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Protein CLEC16A, C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}, CLEC16A (HGNC:29013), KIAA0350