Description
CLP-290 is a novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257, that is highly selective for KCC2 over related Cl- transporters.
CLP-290 is a novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257, that is highly selective for KCC2 over related Cl- transporters.
Alternate Name/Synonyms: [5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 1181083-81-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₁FN₄O₃S
Molecular Weight: 404.46
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257
MDL Number: N/A
PubChem CID: 44188755
SMILES: C1CCN(NC1)C2=NC(=O)C(=CC3=C(C=C(C=C3)F)OC(=O)N4CCCC4)S2
InChi: InChI=1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-
InChi Key: DIXMMXNNKLCLOM-WJDWOHSUSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |