CNOT4 Antibody [APR03986G]

CNOT4 Antibody [APR03986G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This CNOT4 antibody is generated from rabbits immunized with human CNOT4 recombinant protein.

Cellular Localisation: Cytoplasm. Nucleus.

Molecular Weight: 63510

Clone: Polyclonal

Gene Name: CNOT4

Gene ID: 4850

Function: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292) . Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038) . Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292) . Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391) . As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC, IHC-P

Dilution: IHC-P--1:250 FC--1:25 WB--1:2000

Synonyms: CCR4-NOT transcription complex subunit 4, 632-, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, Potential transcriptional repressor NOT4Hp, CNOT4, NOT4