Description
CNOT4 Antibody [APR03986G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This CNOT4 antibody is generated from rabbits immunized with human CNOT4 recombinant protein.
Cellular Localisation: Cytoplasm. Nucleus.
Molecular Weight: 63510
Clone: Polyclonal
Gene Name: CNOT4
Gene ID: 4850
Function: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292) . Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038) . Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292) . Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391) . As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC, IHC-P
Dilution: IHC-P--1:250 FC--1:25 WB--1:2000
Synonyms: CCR4-NOT transcription complex subunit 4, 632-, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, Potential transcriptional repressor NOT4Hp, CNOT4, NOT4