Compound E | 1949

Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM), only weakly affects the presenilase activity.

Compound E is a potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM), only weakly affects the presenilase activity.

1949 | Compound E DataSheet

Alternate Name/Synonyms: (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 209986-17-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₄F₂N₄O₃

Molecular Weight: 490.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent, selective inhibitor of γ-secretase

MDL Number: N/A

PubChem CID: 11306390

SMILES: CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F

InChi: InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1

InChi Key: JNGZXGGOCLZBFB-IVCQMTBJSA-N