Coumarin-SAHA | B2805

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is quenched by 50% when bound to HDAC8.

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is quenched by 50% when bound to HDAC8.

B2805 | Coumarin-SAHA DataSheet

Alternate Name/Synonyms: Coumarin-suberoylanilide hydroxamic acid, N1-Hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)octanediamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1260635-77-5

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₈H₂₂N₂O₅

Molecular Weight: 346.38

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~5 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: It is a class I and class II histone deacetylase (HDAC) inhibitor

MDL Number:

PubChem CID: 53393956

SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO

InChi: InChI=1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22)

InChi Key: YSRCADVJNRJJAV-UHFFFAOYSA-N