SAHA-Bpyne | B2840

SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native proteomes and live cells. It labels HDAC complex proteins in proteomes at 100 nM and in live cells at 500 nM. It shows an IC₅₀ value of ~3 μM for inhibiting HDAC activity in HeLa cell nuclear lysates.

SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native proteomes and live cells. It labels HDAC complex proteins in proteomes at 100 nM and in live cells at 500 nM. It shows an IC₅₀ value of ~3 μM for inhibiting HDAC activity in HeLa cell nuclear lysates.

B2840 | SAHA-Bpyne DataSheet

Alternate Name/Synonyms: Click Tag™ SAHA-Bpyne; Suberoylanilide Hydroxamic Acid-Bpyne; N1-hydroxy-N8-[4-[4-[(1-oxo-5-hexyn-1-yl)amino]benzoyl]phenyl]-octanediamide

Appearance:

Formulation: A solution in methanol

CAS Number: 930772-88-6

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₇H₃₁N₃O₅

Molecular Weight: 477.6

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~5 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A SAHA derivative with a click tag

MDL Number:

PubChem CID: 90276494

SMILES: O=C(CCCCCCC(NO)=O)NC1=CC=C(C(C2=CC=C(NC(CCCC#C)=O)C=C2)=O)C=C1

InChi: InChI=1S/C27H31N3O5/c1-2-3-6-9-24(31)28-22-16-12-20(13-17-22)27(34)21-14-18-23(19-15-21)29-25(32)10-7-4-5-8-11-26(33)30-35/h1,12-19,35H,3-11H2,(H,28,31)(H,29,32)(H,30,33)

InChi Key: VHTATGLVGGHVIS-UHFFFAOYSA-N