BW
COUP-TFI polyclonal Antibody | GCP117
- SKU:
- BW-GCP117
- Availability:
- Usually ships in 5 working days
Description
COUP-TFI polyclonal Antibody | GCP117 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Pig
Application: WB
Application Range: WB: 1:5000~1:10000
Background: Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: COUP-TFI polyclonal Antibody detects endogenous levels of COUP-TFI protein.
Molecular Weight: ~ 52 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2; NR2F2; ARP1, TFCOUP2
Immunogen: Synthetic peptide, corresponding to Human COUP-TFI.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A